We flew in and out of the Tuxtla airport for its cost and convenience to the other places we wanted to visit while in the area. In our research, my husband and I had read that Tuxtla was not a tourist-friendly town but we really enjoyed our time there.
Getting from the airport to town was more expensive than I would have liked but it made the most sense. Supposedly there is a way to take a colectivo from the airport into town but the airport is about 30 minutes away from the city center, and I'm glad we paid for the taxi instead of wasting time trying to figure out the other hypothetical option. It cost $280 MXN which when we visiting in February of 2014 the exchange rate was $13 MXN to $1 USD.
We spent a lot of time just walking around Tuxtla and eating food. No one seemed to be interested in us which was a nice change from the more tourist-heavy areas of Mexico and a great introduction to Chiapas.
Food was pretty cheap and there are taquerias everywhere. A plate of three tacos was about $35 MXN. The only issue I ran into was that most restaurants don't serve hard liquor (I am not a beer drinker) and even a few bars only served beer.
We also took the orange autobuses (which are different than the colectivos) up and down Calle Belisario for 6 MXN per ride. This took us to Parque Central which seems to host an array of events; music, market, etc. But we stayed further west on Calle Belisario near a university in a Holiday Inn. We used points for our stay so I can't comment on pricing for hotels in the area.
There is a nice athletic park at the intersection of Calle Belisario and Calle Libramiento Pontiente Norte which has a track around the outside and soccer fields and playgrounds on the inside. It's a great place to wander around, relax in the shade, or take in a game.